Isolation and amino acid sequences of opossum vasoactive intestinal polypeptide and cholecystokinin octapeptide.
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چکیده
منابع مشابه
Isolation and amino acid sequences of opossum vasoactive intestinal polypeptide and cholecystokinin octapeptide.
Evolutionary history suggests that the marsupials entered South America from North America about 75 million years ago and subsequently dispersed into Australia before the separation between South America and Antarctica-Australia. A question of interest is whether marsupial peptides resemble the corresponding peptides of Old or New World mammals. Previous studies had shown that "little" gastrin ...
متن کامل[Vasoactive intestinal polypeptide (V.I.P)].
VIPomas can occur as part of the type 1 multiple endocrine neoplasia (MEN) syndrome. VIP is the principal mediator of the watery diarrhea syndrome (also known as pancreatic cholera, Werner-Morrison syndrome, or diarrheogenic islet cell tumor). Watery diarrhea syndrome, with elevated VIP, has also been associated with neurogenic tumors (ganglioneuroma, neuroblastoma, pheochromocytoma), bronchoge...
متن کاملRole of vasoactive intestinal polypeptide in the internal anal sphincter relaxation of the opossum.
The nature of the inhibitory neurotransmitter responsible for internal anal sphincter (IAS) relaxation in response to rectoanal reflex is not known. The objective of the present investigation was to examine the role of VIP in IAS relaxation in response to the rectoanal reflex in intact opossums with the use of VIP antagonists, [4CI-D-Phe6,Leu17] VIP and (N-AC-Tyr1,D-Phe2)-GRF (1-29)-NH2. Intral...
متن کاملStructure-activity studies of vasoactive intestinal polypeptide.
This report explores the potential side-chain functional groups required for interaction of the bronchodilator neuropeptide, vasoactive intestinal peptide (VIP), with its receptor. The binding affinity and biological activity of native VIP have been found to be sensitive to the removal of amino- and carboxyl-terminal residues. This data suggests that elements within the entire primary sequence ...
متن کاملVasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide receptor chimeras reveal domains that determine specificity of vasoactive intestinal polypeptide binding and activation.
Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are closely related G protein-coupled receptors with seven-transmembrane domains. The VIP receptor can bind both VIP and PACAP with high affinity, whereas the PACAP receptor binds only PACAP with high affinity. To elucidate the structural domains involved in a selectivity for VIP bin...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1992
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.89.5.1809